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Chai Discovery

Research Engineer, ML Infrastructure

San Francisco office
Level
Mid

Not stated in the posting: salary, work type, visa.

Open. First seen 2 October 2026.

About the role

Chai Discovery's standard text

About Chai Discovery

Chai Discovery builds the computer-aided design suite for molecules. Eli Lilly, GSK, Pfizer, Bristol Meyers, argenx and Novartis all use Chai to power drug discovery programs. AI is reinventing life sciences the same way it reinvented software engineering, and our team is building that future.

We train frontier models that learn the underlying foundations of biochemical structure and interaction. We pair this with a computational workspace to iterate on molecules from idea to medicine, helping scientists move faster and develop medicines beyond the reach of existing methods.

We value diverse perspectives and are ready to find greatness in unexpected places.

About the role

Make our models performant, resource efficient and reliable at scale by developing the core frameworks for model training and evaluation, in close partnerships with fellow researchers and engineers.

  • Build our training stack across model, layer, and kernel levels; optimize workloads through parallelism, quantization, and custom kernels.
  • Profile end-to-end training runs on large GPU clusters; eliminate bottlenecks and failures; monitor throughput, utilization, and uptime.
  • Ensure new model architectures and training recipes scale efficiently, from early experiments to frontier-scale runs.
  • Make our ML training stack maximally reliable: fault tolerance, checkpointing, and deterministic orchestration for long-running, large-scale jobs.

Chai's models are moving beyond protein structure prediction into real-world therapeutic engineering. This is a chance to push the frontier of AI drug design, working alongside a rigorous and craft-obsessed team.

About you

Ideal backgrounds include deep industry experience working with top AI/ML teams on the kinds of problems and systems we describe above—with strong software system design skills, proficiency in Python, and Pytorch or JAX fluency. We look for technical spikes where you have gone deep and demonstrated exceptional impact on real-world problems and systems.

Chai Discovery's standard text

We offer

The opportunity to work at the vanguard of AI research and frontier biology, with world-class people, on a mission that matters. We protect & promote a culture of high velocity and ownership. We compensate our team accordingly.

What this role asks for

Standard for data science / ML roles

PyTorch · Python

Common in data science / ML postings at any company.

56% of this description is written for the role. The rest is Chai Discovery's standard text, folded away below.

Read against Chai Discovery's other open postings on this site.

The team: Research HIRES STEADILY

This role is one of 4 open in Research. 2 were posted in the last 30 days and the oldest in September: a team that hires all year rather than one being built.

WHAT THE TEAM WORKS WITH, ACROSS ITS POSTINGS

Python (3 of 4), PyTorch (3 of 4)

OTHER ROLES ON THIS TEAM

From the team and dates on Chai Discovery's own job board.

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